GeSiM Gesellschaft fuer Silizium-Mikrosysteme mbH

Gesim 1018
The German GeSiM is a leading supplier of instrumentation and services for Low-Volume Liquid Handling, Microfluidics, 3D Bio-Printing and small-scale synthesis.

GeSiM is specialized in liquid handling automation, microfluidics and micro contact printing.


Pico- and Nanoliter Pipetting with the NanoPlotter

Gesim nano-plotter RS
As a leading supplier of submicroliter dispensers GeSiM developed a unique design for piezoelectric pipetting tips, based on silicon-glass chips.

The benchtop pipetting system Nano-Plotter runs up to 16 of these accurate dispensers. The Nano-Plotter line follows a strictly modular concept and "grows" with the applications of their owners.
Common Applications:
  • Non-contact arraying of microarrays
  • Precision spotting of biochips and biosensors.
  • Small volume delivery for Compound Screening Assays in Drug Discovery
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with the

Gesim BioScaffolder BS31 RS

Interested in rapid prototyping or tissue printing for 3D cell culture and regenerative medicine? Look no further. The GESIM BioScaffolder, version 3.1, prints 3D scaffolds and also seeds cells using the well-known GESIM piezoelectric pipettes. The new multi-Z-drives can print different materials at various pressures and temperatures, without exchanging cartridges. Many additional tools can be mounted
Common Applications:
  • Production of 3D scaffolds as support for cell culture and organoids
  • Piezoelectric (ink-jet) microdispensing to coat scaffolds by e.g. matrix proteins
  • Printing of live cells (“organ printing”), either embedded in scaffold material or seeded by piezo spotting
  • Plotting of conductive polymers as sensor material or as coating for medical devices
  • Dispensing of photosensitive material and UV curing (option)
  • Option: Directed melt-electrospinning (MES) to produce fine polymer meshes
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BioSyntheSizer –
Robotic Platform

Gesim biosynthesizer RS
Configurable with a high-pressure, high temperature single vial reaction chamber, a crimping tool as well as powder dispenser and septum piercing luer-needle pipetting tools. This system is already being applied as a multisynthesis radiopharmaceutical robot to create [18F]FDG, [18F]FLT, [18F]FMISO, [18F]NaF, [18F]FES, [18F]FET, [18F]SFB-peptides and [68Ga]peptides.
Common Applications:
  • Synthesis of radiotracers for positron emission tomography (PET)
  • Synthesis of bio-active compounds for medicinal chemistry
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Flexible and Fully Automatic Patterning Platform

GeSIM MicrocontentPrinter 0817 small
The µContact-Printer 4.1 (µCP 4.1) features PDMS stamps with customized stamp patterns. It offers surface patterning at the submicrometer range as well as Nano-Imprint Lithography on one instrument. It fits into standard laboratory safety cabinets and is highly customizable.

Microcontact printing (µCP) does work on the nanoscale: a soft polymer like PDMS (silicone) is cast on a micro- or nanostructured master; the resulting stamp is soaked in sample and pressed onto a surface, thus transferring molecules from the protruding areas. Chemicals, biomolecules, nanoparticles, beads and cells can be printed, which is why µCP is getting popular in the life sciences, e.g. to study the influence of structured matrix proteins or growth factors on growth, differentiation and movement of cells.

Nanoimprint lithography (NIL) has become a hot topic in microelectronics and cell biology. Here the entire stamp structure is replicated in a soft polymer at elevated temperature and fixed by cooling or UV cross-linking. µCP and NIL are easily performed on the fully automatic GeSiM µContactPrinter 4.1, taking the risk out of both methods. Smaller structures can be tiled together via step & repeat, especially when using “double-side patterning” with a silicon mask in the stamp. For higher throughput, the larger µCP 4.2 exists.
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